Instituto de Biotecnología

Agustin Hidalgo Gutierrez

Correo electrónico: ahg@ugr.es

Currículum Vitae

I have always felt passion for biomedicine. After completing my Bachelor's degree in Biology at the University of Granada (UGR) in 2014, I joined the Intercellular Communication group to pursue a Master’s in Biotechnology, supported by the UGR Initiation to Research Fellowship and a competitive contract from the Government of Spain. I then began my doctoral thesis in biomedicine, focused on a preclinical study for the treatment of mitochondrial encephalopathy due to Coenzyme Q deficiency, funded by the prestigious FPU fellowship During my PhD, I enriched my training through international research stays at the University of Nottingham (UK), Columbia University (USA), and the Albert Heck Laboratory at Utrecht University (The Netherlands). My scientific production includes 23 publications, with 7 as first or co- first author. My work has contributed to understanding pathological mechanisms such as altered hydrogen sulfide metabolism, one-carbon metabolism in CoQ deficiencies, and to proposing therapeutic strategies including the use of beta-resorcylic acid (b-RA) for Coq9 deficiency and obesity, the latter patented in Europe, Mexico, Australia, and the USA. I defended my thesis with Cum Laude on 11 December 2020 and continued at UGR with a postdoctoral contract, which allowed me to teach for five years in the Faculties of Medicine and Nursing and receiving excellent student evaluations, including the highest score in mentorship. In January 2022, I was awarded the Alfonso Martín Escudero fellowship (FAME) for a two-year postdoctoral stay at Columbia University under the mentorship of Prof. Michio Hirano. I subsequently secured the highly competitive Marie Curie Global Fellowship, allowing two further years at Columbia University and a third year back at UGR. From 1 July 2025, I have held a double affiliation with Columbia University and UGR, enabling me to resume teaching at the UGR Faculty of Medicine. My contract at Columbia will conclude on 1 January 2026, after four years of research activity. During this period, I completed a translational study on a novel mitochondrial DNA depletion syndrome (MDDS), published in 2024 in Annals of Neurology, which also supported an international patent application on which I am 1st inventor. As final results of my post-doctoral stay at CU, I have one paper under consideration in JCI Insight as 1st author, reporting a short study in which we describe weekly mtDNA quantification in white blood cells of the patients as a biomarker of disease progression. In addition, I have another paper under consideration in Cell Reports as 1st and co-Corresponding Author, where we report and partially characterize the new constitutive and conditional GUK1 mouse models. Throughout my career, I have participated in 16 research projects, serving as principal investigator in 3 of them. In addition, this year I have secured 2 more projects to start my lab in the UGR as PI, one from the FEDER Foundation and another from the Andalusian Regional Ministry of Health, with a budget of €25,000 and €133,00 respectively, demonstrating independence, leadership, and the capacity to develop competitive proposals. This year I also secured my 6th project as PI from the InfraPlus European consortium to study mRNA in the GUK1 model. My dissemination activities include more than 35 national and international conferences, with oral or poster presentations. I have served as discussion leader at the 2024 Mitochondria Gordon Research Seminar, invited speaker at the inaugural Antioxidants webinar and at the 23rd FEPS Conference, and reviewer for over 25 manuscripts in Q1 journals such as BBA Molecular Disease, Nutrients, and Antioxidants. Beyond academia, I promote scientific outreach through my Twitter channel MITO-GARAGE and Linkedin, participation in the rare diseases radio program from Radio Libertad, and NAMDC educational sessions. My work has received significant recognition, including awards for the Best Doctoral Thesis from both the Spanish Society of Physiological Sciences (SECF) and the UGR, finalist for the Royal Academy of Doctors of Spain (RADE) Thesis Awards, month associate of FAME, and the SEBMM award for Best Article of the Month for my work in EMBO Molecular Medicine in 2019. In October, I was awarded a Beatriz Galindo Junior Fellowship; however, I had to decline it due to its incompatibility with an Assistant Professor position later offered by the UGR. This position will formally begin on 1st July 2026 after the completion of the Marie Curie Global fellowship. In summary, my trajectory reflects sustained dedication to high-quality biomedical research, international collaboration, competitive funding acquisition, impactful publications, teaching excellence, and active dissemination.

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